N-Heterocyclic Carbene Catalysis under Oxidizing Conditions

N-heterocyclic carbene organocatalysis under oxidizing conditions provides a vast range of various synthetic procedures via diverse mechanisms. The available catalysts, bases, oxidants, and oxidizing methods afford numerous opportunities for developing this branch of organocatalysis. Furthermore, implementation of tandem reactions and cooperative catalysis in the described methodology significantly expands the possibilities of modern organic chemistry. This approach allows the synthesis of different structurally complex and often enantiomerically enriched substances, which can be interesting in terms of biological activity and natural product synthesis. Many esters, amides, thioesters, lactams, lactones, and other cyclic compounds obtained in oxidative or oxygenative reactions promoted by N-heterocyclic carbenes can be interesting precursors in advanced organic synthesis. Sophistication and broad applicability prove that the described synthetic approaches are exceptionally worthy of further development.


Introduction
N-heterocyclic carbene (NHCs) catalysis is constantly developing as a diverse strategy for the synthesis of complex organic molecules. NHC-catalyzed reactions enable the formation of many carbon-carbon and carbon-heteroatom bonds, including heterocyclic rings [1][2][3][4][5][6][7][8]. N-heterocyclic carbenes were originally applied in umpolung benzoin condensation [9], which is still the most examined NHC-catalyzed reaction model [10]. In this type of reaction, a Breslow intermediate is generated after the nucleophilic attack of carbene on a carbonyl carbon atom. Moreover, this intermediate exhibits nucleophilic properties, in contrast to carbonyl compounds which are typically electrophilic agents (Figure 1) [11].
This review contains examples of a broad range of oxygenative or oxidative NHC-catalyzed reactions, which are crucial for modern organic synthesis. The article is focused on the application of NHC catalysis under oxidizing conditions, as an example of cooperative catalysis with the use of an external oxidant [30]. The aim of this work is also the nomenclature overview of this significant and relevant synthetic approach, and a breakdown by oxidation path. Moreover, this review is aimed at updating the status of NHC-catalyzed reactions under oxidizing conditions in existing review papers [31,32].

Mechanistic and Nomenclature Issues
Oxidative NHC catalysis, similarly to the classical umpolung process, is initiated by the Breslow intermediate, which is generated from a N-heterocyclic carbene and carbonyl compound-typically aldehyde. An acylazolium ion, which is electrophilic acylium cation synthon, is formed via transfer of two electrons from the mentioned intermediate to the oxidant in the reaction mixture. The nucleophile added as a reactant undergoes nucleophilic substitution to the carbonyl group of the acylazolium ion, with subsequent elimination of the azolium cation and regeneration of the catalyst ( Figure 2) [31]. On the other hand, the Breslow intermediate can be oxidized via oxygen atom transfer from an oxidizing agent. After formation of a peroxide zwitterion, a second molecule of aldehyde is oxidized by the peroxide species, then the azolium intermediate is eliminated and the carboxylate ion is formed. Next, the obtained carboxylate participate in the reaction with an electrophile is added to the reaction mixture. This path is called oxygenative NHC catalysis, in contrast to the oxidative path ( Figure 3). In oxygenative carboxylations, molecular oxygen can be used as external oxidant. In the

Mechanistic and Nomenclature Issues
Oxidative NHC catalysis, similarly to the classical umpolung process, is initiated by the Breslow intermediate, which is generated from a N-heterocyclic carbene and carbonyl compound-typically aldehyde. An acylazolium ion, which is electrophilic acylium cation synthon, is formed via transfer of two electrons from the mentioned intermediate to the oxidant in the reaction mixture. The nucleophile added as a reactant undergoes nucleophilic substitution to the carbonyl group of the acylazolium ion, with subsequent elimination of the azolium cation and regeneration of the catalyst (Figure 2) [31].

Mechanistic and Nomenclature Issues
Oxidative NHC catalysis, similarly to the classical umpolung process, is initiated by the Breslow intermediate, which is generated from a N-heterocyclic carbene and carbonyl compound-typically aldehyde. An acylazolium ion, which is electrophilic acylium cation synthon, is formed via transfer of two electrons from the mentioned intermediate to the oxidant in the reaction mixture. The nucleophile added as a reactant undergoes nucleophilic substitution to the carbonyl group of the acylazolium ion, with subsequent elimination of the azolium cation and regeneration of the catalyst ( Figure 2) [31]. On the other hand, the Breslow intermediate can be oxidized via oxygen atom transfer from an oxidizing agent. After formation of a peroxide zwitterion, a second molecule of aldehyde is oxidized by the peroxide species, then the azolium intermediate is eliminated and the carboxylate ion is formed. Next, the obtained carboxylate participate in the reaction with an electrophile is added to the reaction mixture. This path is called oxygenative NHC catalysis, in contrast to the oxidative path ( Figure 3). In oxygenative carboxylations, molecular oxygen can be used as external oxidant. In the On the other hand, the Breslow intermediate can be oxidized via oxygen atom transfer from an oxidizing agent. After formation of a peroxide zwitterion, a second molecule of aldehyde is oxidized by the peroxide species, then the azolium intermediate is eliminated and the carboxylate ion is formed. Next, the obtained carboxylate participate in the reaction with an electrophile is added to the reaction mixture. This path is called oxygenative NHC catalysis, in contrast to the oxidative path ( Figure 3). In oxygenative carboxylations, molecular oxygen can be used as external oxidant. In the Moreover, the oxygenative path is not the only possible reaction mechanism in the case of using molecular oxygen as an oxidant. An acylazolium ion can be formed after elimination of a hydroperoxyl anion from the peroxide zwitterion. This path is also oxidative NHC catalysis, because an acylazolium intermediate is generated [33].

Oxygenative NHC Catalysis
Oxygenative NHC catalysis was first reported by Deng's group in 2010 (Figure 4a) [35]. Benzyl benzoate derivatives were obtained with good yields in the reaction of benzaldehydes with benzyl bromides under aerobic conditions, using a thiazolium catalyst. Similar syntheses were described one year later by Liu et al. [36]. They involved reactions between cinnamaldehydes and cinnamyl bromides or allyl bromides using a benzimidazolium catalyst (Figure 4b). Moreover, the authors used as an oxidant not only molecular oxygen, but also manganese(IV) oxide. Moreover, the oxygenative path is not the only possible reaction mechanism in the case of using molecular oxygen as an oxidant. An acylazolium ion can be formed after elimination of a hydroperoxyl anion from the peroxide zwitterion. This path is also oxidative NHC catalysis, because an acylazolium intermediate is generated [33].

Oxygenative NHC Catalysis
Oxygenative NHC catalysis was first reported by Deng's group in 2010 (Figure 4a) [35]. Benzyl benzoate derivatives were obtained with good yields in the reaction of benzaldehydes with benzyl bromides under aerobic conditions, using a thiazolium catalyst. Similar syntheses were described one year later by Liu et al. [36]. They involved reactions between cinnamaldehydes and cinnamyl bromides or allyl bromides using a benzimidazolium catalyst (Figure 4b). Moreover, the authors used as an oxidant not only molecular oxygen, but also manganese(IV) oxide. Hui and co-workers developed a reaction of benzaldehyde with alkyl bromides and tosylates, with 1,3-dimesitylimidazolium chloride as a precatalyst, in which alkyl benzoates were obtained with relatively good yields [37]. In all the aforementioned procedures DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) was used as a base. In turn, in 2011 Youn and co-workers reported the synthesis of phtalides and isocoumarins in oxygenative NHC-catalytic intramolecular reactions of o-alkynyl benzaldehydes [37]. It was the first example of an oxygenative NHC-catalyzed cyclization reaction. Regioselectivity of the examined process depends strongly on the R substituent nature and varies between <99:1 and 17:83 ( Figure 5).   [39]. Imidazolinium salt was used as a precatalyst and potassium carbonate as a base. The expected products were obtained with excellent yields of up to 93%. Hui and co-workers developed a reaction of benzaldehyde with alkyl bromides and tosylates, with 1,3-dimesitylimidazolium chloride as a precatalyst, in which alkyl benzoates were obtained with relatively good yields [37]. In all the aforementioned procedures DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) was used as a base. In turn, in 2011 Youn and co-workers reported the synthesis of phtalides and isocoumarins in oxygenative NHC-catalytic intramolecular reactions of o-alkynyl benzaldehydes [37]. It was the first example of an oxygenative NHC-catalyzed cyclization reaction. Regioselectivity of the examined process depends strongly on the R substituent nature and varies between <99:1 and 17:83 ( Figure 5). Hui and co-workers developed a reaction of benzaldehyde with alkyl bromides and tosylates, with 1,3-dimesitylimidazolium chloride as a precatalyst, in which alkyl benzoates were obtained with relatively good yields [37]. In all the aforementioned procedures DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) was used as a base. In turn, in 2011 Youn and co-workers reported the synthesis of phtalides and isocoumarins in oxygenative NHC-catalytic intramolecular reactions of o-alkynyl benzaldehydes [37]. It was the first example of an oxygenative NHC-catalyzed cyclization reaction. Regioselectivity of the examined process depends strongly on the R substituent nature and varies between <99:1 and 17:83 ( Figure 5).   [39]. Imidazolinium salt was used as a precatalyst and potassium carbonate as a base. The expected products were obtained with excellent yields of up to 93%.   Hui and co-workers developed a reaction of benzaldehyde with alkyl bromides and tosylates, with 1,3-dimesitylimidazolium chloride as a precatalyst, in which alkyl benzoates were obtained with relatively good yields [37]. In all the aforementioned procedures DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) was used as a base. In turn, in 2011 Youn and co-workers reported the synthesis of phtalides and isocoumarins in oxygenative NHC-catalytic intramolecular reactions of o-alkynyl benzaldehydes [37]. It was the first example of an oxygenative NHC-catalyzed cyclization reaction. Regioselectivity of the examined process depends strongly on the R substituent nature and varies between <99:1 and 17:83 ( Figure 5).   [39]. Imidazolinium salt was used as a precatalyst and potassium carbonate as a base. The expected products were obtained with excellent yields of up to 93%.  Imidazolinium salt was used as a precatalyst and potassium carbonate as a base. The expected products were obtained with excellent yields of up to 93%.

Oxidative NHC Catalysis
Synthesis of esters and carboxylic acids via oxidative NHC catalysis with the addition of alcohols or water, respectively, as nucleophiles is a well-developed reaction model. It is especially worth noting the research published by, among others, Struder, Zeitler or Scheidt [40][41][42][43][44][45][46][47][48][49]. Initially, the oxidative path was applied to the synthesis of benzoic acid esters derivatives. Connon et al. reported the synthesis of similar species in the reaction of benzaldehydes with primary and secondary alcohols in 2008 ( Figure 7) [50]. In this case, azobenzene was used as an oxidizer and 3-benzylthiazolium bromide as a precatalyst.

Oxidative NHC Catalysis
Synthesis of esters and carboxylic acids via oxidative NHC catalysis with the addition of alcohols or water, respectively, as nucleophiles is a well-developed reaction model. It is especially worth noting the research published by, among others, Struder, Zeitler or Scheidt [40][41][42][43][44][45][46][47][48][49]. Initially, the oxidative path was applied to the synthesis of benzoic acid esters derivatives. Connon et al. reported the synthesis of similar species in the reaction of benzaldehydes with primary and secondary alcohols in 2008 ( Figure 7) [50]. In this case, azobenzene was used as an oxidizer and 3-benzylthiazolium bromide as a precatalyst. Maki and Scheidt developed the oxidative reaction of aliphatic aldehydes with alcohols catalyzed by carbene liberated from 1,3-dimethylimidazolium iodide [41]. Manganese(IV) oxide was used as an external oxidizer, and the expected products were obtained with very high yields of up to 99%.
It is also possible to design tandem oxidation reactions in which one step is the NHC-catalyzed oxidation process. Rose and Zeitler performed a domino protocol of the oxidation of 2-(hydroxyethoxy)benzyl alcohols to cyclic lactones in 2010 ( Figure 8) [45]. In the first step, a benzyl hydroxyl group was oxidized to aldehyde by manganese(IV) oxide and, then, the intramolecular reaction of oxidative NHC-catalyzed esterification occurred. Azobenzene was used in this case as an equimolar oxidizer. Kang and Jang published a similar reaction of esterification of allyl alcohols resulting in allyl cinnamates formation in 2014 ( Figure 9) [51]. In the first step, allyl alcohol is oxidized by TEMPO ((2,2,6,6-Tetramethylpiperidin-1-yl)oxyl) to aldehyde, which reacts then with the carbene present in the reaction mixture. Oxidation of the Breslow intermediate is followed by TEMPO in two steps via SET, and results in a radical cation formation which is finally oxidized to an acylazolium. High yields of oxidative esterification are promoted by the addition of hexafluoroisopropyl alcohol (HFIP). Moreover, the oxidizer is recyclable because it undergoes oxidation by oxygen from air.  Maki and Scheidt developed the oxidative reaction of aliphatic aldehydes with alcohols catalyzed by carbene liberated from 1,3-dimethylimidazolium iodide [41]. Manganese(IV) oxide was used as an external oxidizer, and the expected products were obtained with very high yields of up to 99%.
It is also possible to design tandem oxidation reactions in which one step is the NHC-catalyzed oxidation process.
Rose and Zeitler performed a domino protocol of the oxidation of 2-(hydroxyethoxy)benzyl alcohols to cyclic lactones in 2010 ( Figure 8) [45]. In the first step, a benzyl hydroxyl group was oxidized to aldehyde by manganese(IV) oxide and, then, the intramolecular reaction of oxidative NHC-catalyzed esterification occurred. Azobenzene was used in this case as an equimolar oxidizer.

Oxidative NHC Catalysis
Synthesis of esters and carboxylic acids via oxidative NHC catalysis with the addition of alcohols or water, respectively, as nucleophiles is a well-developed reaction model. It is especially worth noting the research published by, among others, Struder, Zeitler or Scheidt [40][41][42][43][44][45][46][47][48][49]. Initially, the oxidative path was applied to the synthesis of benzoic acid esters derivatives. Connon et al. reported the synthesis of similar species in the reaction of benzaldehydes with primary and secondary alcohols in 2008 (Figure 7) [50]. In this case, azobenzene was used as an oxidizer and 3-benzylthiazolium bromide as a precatalyst. Maki and Scheidt developed the oxidative reaction of aliphatic aldehydes with alcohols catalyzed by carbene liberated from 1,3-dimethylimidazolium iodide [41]. Manganese(IV) oxide was used as an external oxidizer, and the expected products were obtained with very high yields of up to 99%.
It is also possible to design tandem oxidation reactions in which one step is the NHC-catalyzed oxidation process. Rose and Zeitler performed a domino protocol of the oxidation of 2-(hydroxyethoxy)benzyl alcohols to cyclic lactones in 2010 ( Figure 8) [45]. In the first step, a benzyl hydroxyl group was oxidized to aldehyde by manganese(IV) oxide and, then, the intramolecular reaction of oxidative NHC-catalyzed esterification occurred. Azobenzene was used in this case as an equimolar oxidizer. Kang and Jang published a similar reaction of esterification of allyl alcohols resulting in allyl cinnamates formation in 2014 ( Figure 9) [51]. In the first step, allyl alcohol is oxidized by TEMPO ((2,2,6,6-Tetramethylpiperidin-1-yl)oxyl) to aldehyde, which reacts then with the carbene present in the reaction mixture. Oxidation of the Breslow intermediate is followed by TEMPO in two steps via SET, and results in a radical cation formation which is finally oxidized to an acylazolium. High yields of oxidative esterification are promoted by the addition of hexafluoroisopropyl alcohol (HFIP). Moreover, the oxidizer is recyclable because it undergoes oxidation by oxygen from air.  Kang and Jang published a similar reaction of esterification of allyl alcohols resulting in allyl cinnamates formation in 2014 ( Figure 9) [51]. In the first step, allyl alcohol is oxidized by TEMPO ((2,2,6,6-Tetramethylpiperidin-1-yl)oxyl) to aldehyde, which reacts then with the carbene present in the reaction mixture. Oxidation of the Breslow intermediate is followed by TEMPO in two steps via SET, and results in a radical cation formation which is finally oxidized to an acylazolium. High yields of oxidative esterification are promoted by the addition of hexafluoroisopropyl alcohol (HFIP). Moreover, the oxidizer is recyclable because it undergoes oxidation by oxygen from air.
cinnamates formation in 2014 ( Figure 9) [51]. In the first step, allyl alcohol is oxidized by TEMPO ((2,2,6,6-Tetramethylpiperidin-1-yl)oxyl) to aldehyde, which reacts then with the carbene present in the reaction mixture. Oxidation of the Breslow intermediate is followed by TEMPO in two steps via SET, and results in a radical cation formation which is finally oxidized to an acylazolium. High yields of oxidative esterification are promoted by the addition of hexafluoroisopropyl alcohol (HFIP). Moreover, the oxidizer is recyclable because it undergoes oxidation by oxygen from air.  As mentioned, the Kang and Jang method can be recognized as one of the first examples of the exceptional cooperative NHC-catalyzed oxidative reaction which occurs with the use of electron-transfer mediators (ETMs). Studer's group reported an aerobic NHC-catalyzed oxidation of aldehydes to esters in 2013 ( Figure 10) [52]. Oxygen from air is not a direct oxidizer but oxidizes the ruthenium(I) complex generated via reduction of the ruthenium(II) complex added to the reaction mixture. The ruthenium(II) complex participates in Breslow intermediate oxidation to acylazolium. This approach, with the use of ruthenium complexes as ETMs, prevents aerobic oxidation of aldehydes to carboxylic acids and enables the expected products to be obtained with moderate to good yields. Moreover, during cooperative oxidative NHC catalysis, less than equimolar amounts of direct oxidizers are used. As mentioned, the Kang and Jang method can be recognized as one of the first examples of the exceptional cooperative NHC-catalyzed oxidative reaction which occurs with the use of electrontransfer mediators (ETMs). Studer's group reported an aerobic NHC-catalyzed oxidation of aldehydes to esters in 2013 ( Figure 10) [52]. Oxygen from air is not a direct oxidizer but oxidizes the ruthenium(I) complex generated via reduction of the ruthenium(II) complex added to the reaction mixture. The ruthenium(II) complex participates in Breslow intermediate oxidation to acylazolium. This approach, with the use of ruthenium complexes as ETMs, prevents aerobic oxidation of aldehydes to carboxylic acids and enables the expected products to be obtained with moderate to good yields. Moreover, during cooperative oxidative NHC catalysis, less than equimolar amounts of direct oxidizers are used. Sundén and co-workers reported the aerobic NHC-catalyzed synthesis of dihydropyranones via multistep electron transfer in 2016 ( Figure 11) [53]. The assumption of this work is the oxidation of ETM first, by oxygen from air. The first ETM oxidizes, then the second ETM, which is the final oxidizer in the NHC-catalyzed reaction. The expected dihydropyranones were obtained with moderate to good yields and excellent enantiomeric excesses. In the same year, Sundén's group reported similar oxidative esterification of aldehydes [54]. Moreover, iron [48] and palladium [55] compounds were also recognized as ETMs in similar reactions.  Figure 12) [56]. Various carboxylic acids were obtained with moderate to good yields. Furthermore, the authors considered that the possible oxygenative path of the investigated mechanism occurs in the minority of cases. Sundén and co-workers reported the aerobic NHC-catalyzed synthesis of dihydropyranones via multistep electron transfer in 2016 ( Figure 11) [53]. The assumption of this work is the oxidation of ETM first, by oxygen from air. The first ETM oxidizes, then the second ETM, which is the final oxidizer in the NHC-catalyzed reaction. The expected dihydropyranones were obtained with moderate to good yields and excellent enantiomeric excesses. In the same year, Sundén's group reported similar oxidative esterification of aldehydes [54]. Moreover, iron [48] and palladium [55] compounds were also recognized as ETMs in similar reactions.  Figure 10) [52]. Oxygen from air is not a direct oxidizer but oxidizes the ruthenium(I) complex generated via reduction of the ruthenium(II) complex added to the reaction mixture. The ruthenium(II) complex participates in Breslow intermediate oxidation to acylazolium. This approach, with the use of ruthenium complexes as ETMs, prevents aerobic oxidation of aldehydes to carboxylic acids and enables the expected products to be obtained with moderate to good yields. Moreover, during cooperative oxidative NHC catalysis, less than equimolar amounts of direct oxidizers are used. Sundén and co-workers reported the aerobic NHC-catalyzed synthesis of dihydropyranones via multistep electron transfer in 2016 ( Figure 11) [53]. The assumption of this work is the oxidation of ETM first, by oxygen from air. The first ETM oxidizes, then the second ETM, which is the final oxidizer in the NHC-catalyzed reaction. The expected dihydropyranones were obtained with moderate to good yields and excellent enantiomeric excesses. In the same year, Sundén's group reported similar oxidative esterification of aldehydes [54]. Moreover, iron [48] and palladium [55] compounds were also recognized as ETMs in similar reactions.  Figure 12) [56]. Various carboxylic acids were obtained with moderate to good yields. Furthermore, the authors considered that the possible oxygenative path of the investigated mechanism occurs in the minority of cases.  Figure 12) [56]. Various carboxylic acids were obtained with moderate to good yields. Furthermore, the authors considered that the possible oxygenative path of the investigated mechanism occurs in the minority of cases. Direct oxidation of the Breslow intermediate to acylazolium by oxygen from air is also possible. Blechert et al. reported the NHC-catalyzed oxidation of aldehydes to carboxylic acids with the addition of mesoporous graphitic carbon nitride (mpg-C3N4) as a photocatalyst in 2013 ( Figure 12) [56]. Various carboxylic acids were obtained with moderate to good yields. Furthermore, the authors considered that the possible oxygenative path of the investigated mechanism occurs in the minority of cases.   [57]. Various esters were obtained with moderate yields without the addition of ETMs or other catalysts. In this case, 1,3-dimesitylimidazolium chloride was used as a precatalyst and DBU as a base. The reaction was carried out in THF with the addition of methanol as a reagent. Shortly thereafter, Zeitler and Connon showed a similar aerobic oxidation of aromatic aldehydes, but in general with better yields [58]. In their procedure, triazolium salt was used as a precatalyst, DBU as a base, and THF as a solvent. Nonetheless, a considerable excess of methanol as a reactant was added to the reaction mixture.
In 2010, Nair and co-workers reported the NHC-catalyzed oxidation of benzaldehydes to benzoic acids using carbon dioxide as an oxidant [59]. According to the authors, the Breslow intermediate was oxidized by carbon dioxide with the liberation of carbon monoxide. The expected aromatic carboxylic acids were obtained with moderate to high yields. One year earlier, Gu and Zhang presented a catalyzed by NHC oxidation of aromatic aldehydes (including cinnamaldehydes) to carboxylic acids [60]. As an oxidant, carbon dioxide was also used, but the authors provided the mechanism with the NHC-catalyzed step of CO 2 reduction. Gu and Zhang assumed that aldehyde molecules were directly oxidized by oxygen from the carbon dioxide-NHC complex. In this case, products were obtained with differentiated yields. Bode and co-workers published an article developing earlier research into the oxidizing properties of carbon dioxide in NHC catalysis in 2011 [61]. Their experiments proved that molecular oxygen, instead of CO 2 , plays the role of the oxidizing agent in the mentioned reactions ( Figure 13). Nonetheless, carbon dioxide prevents formation of side products via aldehyde dimerization or oligomerization.  [57]. Various esters were obtained with moderate yields without the addition of ETMs or other catalysts. In this case, 1,3-dimesitylimidazolium chloride was used as a precatalyst and DBU as a base. The reaction was carried out in THF with the addition of methanol as a reagent. Shortly thereafter, Zeitler and Connon showed a similar aerobic oxidation of aromatic aldehydes, but in general with better yields [58]. In their procedure, triazolium salt was used as a precatalyst, DBU as a base, and THF as a solvent. Nonetheless, a considerable excess of methanol as a reactant was added to the reaction mixture.
In 2010, Nair and co-workers reported the NHC-catalyzed oxidation of benzaldehydes to benzoic acids using carbon dioxide as an oxidant [59]. According to the authors, the Breslow intermediate was oxidized by carbon dioxide with the liberation of carbon monoxide. The expected aromatic carboxylic acids were obtained with moderate to high yields. One year earlier, Gu and Zhang presented a catalyzed by NHC oxidation of aromatic aldehydes (including cinnamaldehydes) to carboxylic acids [60]. As an oxidant, carbon dioxide was also used, but the authors provided the mechanism with the NHC-catalyzed step of CO2 reduction. Gu and Zhang assumed that aldehyde molecules were directly oxidized by oxygen from the carbon dioxide-NHC complex. In this case, products were obtained with differentiated yields. Bode and co-workers published an article developing earlier research into the oxidizing properties of carbon dioxide in NHC catalysis in 2011 [61]. Their experiments proved that molecular oxygen, instead of CO2, plays the role of the oxidizing agent in the mentioned reactions ( Figure 13). Nonetheless, carbon dioxide prevents formation of side products via aldehyde dimerization or oligomerization. As is well known, reactions promoted by chiral NHC-catalysts enable the synthesis of enantiomerically enriched products. Scheidt's group reported the dessymetrization of cis-1,2-cyclohexanediol by cinnamic aldehyde oxidative esterification in 2007 [62]. They obtained a monocinnamate ester with 80% ee and 58% yield ( Figure 14). In 2011, Iida and Yashima reported an analogous reaction of the dessymetrization of cis-1,2-cyclohexanediol via oxidative catalytic benzoylation using triazolium salt as the NHC precursor and riboflavin as the co-catalyst [49]. Yields and enantiomeric excesses were lower than results showed in Scheidt's work. Notwithstanding, the developed procedure was an aerobic oxidation, which is a considerable advantage. As is well known, reactions promoted by chiral NHC-catalysts enable the synthesis of enantiomerically enriched products.
Scheidt's group reported the dessymetrization of cis-1,2-cyclohexanediol by cinnamic aldehyde oxidative esterification in 2007 [62]. They obtained a monocinnamate ester with 80% ee and 58% yield ( Figure 14).  [57]. Various esters were obtained with moderate yields without the addition of ETMs or other catalysts. In this case, 1,3-dimesitylimidazolium chloride was used as a precatalyst and DBU as a base. The reaction was carried out in THF with the addition of methanol as a reagent. Shortly thereafter, Zeitler and Connon showed a similar aerobic oxidation of aromatic aldehydes, but in general with better yields [58]. In their procedure, triazolium salt was used as a precatalyst, DBU as a base, and THF as a solvent. Nonetheless, a considerable excess of methanol as a reactant was added to the reaction mixture.
In 2010, Nair and co-workers reported the NHC-catalyzed oxidation of benzaldehydes to benzoic acids using carbon dioxide as an oxidant [59]. According to the authors, the Breslow intermediate was oxidized by carbon dioxide with the liberation of carbon monoxide. The expected aromatic carboxylic acids were obtained with moderate to high yields. One year earlier, Gu and Zhang presented a catalyzed by NHC oxidation of aromatic aldehydes (including cinnamaldehydes) to carboxylic acids [60]. As an oxidant, carbon dioxide was also used, but the authors provided the mechanism with the NHC-catalyzed step of CO2 reduction. Gu and Zhang assumed that aldehyde molecules were directly oxidized by oxygen from the carbon dioxide-NHC complex. In this case, products were obtained with differentiated yields. Bode and co-workers published an article developing earlier research into the oxidizing properties of carbon dioxide in NHC catalysis in 2011 [61]. Their experiments proved that molecular oxygen, instead of CO2, plays the role of the oxidizing agent in the mentioned reactions ( Figure 13). Nonetheless, carbon dioxide prevents formation of side products via aldehyde dimerization or oligomerization. As is well known, reactions promoted by chiral NHC-catalysts enable the synthesis of enantiomerically enriched products. Scheidt's group reported the dessymetrization of cis-1,2-cyclohexanediol by cinnamic aldehyde oxidative esterification in 2007 [62]. They obtained a monocinnamate ester with 80% ee and 58% yield ( Figure 14). In 2011, Iida and Yashima reported an analogous reaction of the dessymetrization of cis-1,2-cyclohexanediol via oxidative catalytic benzoylation using triazolium salt as the NHC precursor and riboflavin as the co-catalyst [49]. Yields and enantiomeric excesses were lower than results showed in Scheidt's work. Notwithstanding, the developed procedure was an aerobic  In 2011, Iida and Yashima reported an analogous reaction of the dessymetrization of cis-1,2-cyclohexanediol via oxidative catalytic benzoylation using triazolium salt as the NHC precursor and riboflavin as the co-catalyst [49]. Yields and enantiomeric excesses were lower than results showed in Scheidt's work. Notwithstanding, the developed procedure was an aerobic oxidation, which is a considerable advantage.
You and co-workers developed the oxidative NHC-catalyzed Claisen rearrangement in 2015 [63]. Bicyclic dihydropyranone-fused naphtols were obtained with generally high yields and moderate to good enantiomeric excesses. As an oxidant, the sterically hindered quinone reported in 1957 by Kharasch was used (Figure 15) [64]. More importantly, in this reaction, not only carbon-heteroatom bonds were generated but also a novel carbon-carbon bond was formed ( Figure 16).   Figure 17) [65]. In one of the proposed mechanisms, there occurs a Claisen rearrangement or 1,4-addition, between the generated acylazolium and di(hetero)arylmethane derivative. Another mechanism assumes oxidation via SET. The authors obtained the expected products with high yields and excellent enantioselectivities. In 2018, Yang, Chi and co-workers reported the NHC-catalyzed oxidative acylation of 1,2-diols by aldehydes with high site-selectivities ( Figure 18) [66]. The authors obtained various hydroxyesters acylated at primary hydroxyl groups with moderate yields and enantiomeric excesses.    Figure 17) [65]. In one of the proposed mechanisms, there occurs a Claisen rearrangement or 1,4-addition, between the generated acylazolium and di(hetero)arylmethane derivative. Another mechanism assumes oxidation via SET. The authors obtained the expected products with high yields and excellent enantioselectivities. In 2018, Yang, Chi and co-workers reported the NHC-catalyzed oxidative acylation of 1,2-diols by aldehydes with high site-selectivities ( Figure 18) [66]. The authors obtained various hydroxyesters acylated at primary hydroxyl groups with moderate yields and enantiomeric excesses.   Figure 17) [65]. In one of the proposed mechanisms, there occurs a Claisen rearrangement or 1,4-addition, between the generated acylazolium and di(hetero)arylmethane derivative. Another mechanism assumes oxidation via SET. The authors obtained the expected products with high yields and excellent enantioselectivities.   Figure 17) [65]. In one of the proposed mechanisms, there occurs a Claisen rearrangement or 1,4-addition, between the generated acylazolium and di(hetero)arylmethane derivative. Another mechanism assumes oxidation via SET. The authors obtained the expected products with high yields and excellent enantioselectivities. In 2018, Yang, Chi and co-workers reported the NHC-catalyzed oxidative acylation of 1,2-diols by aldehydes with high site-selectivities ( Figure 18) [66]. The authors obtained various hydroxyesters acylated at primary hydroxyl groups with moderate yields and enantiomeric excesses.  In 2018, Yang, Chi and co-workers reported the NHC-catalyzed oxidative acylation of 1,2-diols by aldehydes with high site-selectivities ( Figure 18) [66]. The authors obtained various hydroxyesters acylated at primary hydroxyl groups with moderate yields and enantiomeric excesses. In 2018, Yang, Chi and co-workers reported the NHC-catalyzed oxidative acylation of 1,2-diols by aldehydes with high site-selectivities ( Figure 18) [66]. The authors obtained various hydroxyesters acylated at primary hydroxyl groups with moderate yields and enantiomeric excesses. Synthesis of amides and thioesters via oxidative NHC-catalyzed reactions is also possible. In 2011, some examples of enantiomerically enriched benzoic acid amides and thioesters were synthesized from benzaldehydes and racemic amines and thiols by Iida and Yashima, with moderate yields and very low enantiomeric excesses below 9% [49].
In 2017, Ma et al. showed that direct N-acylation of amides by aldehydes in oxidative NHC-catalyzed reaction is also possible [67]. Various carboxylic or sulfonic acids amides were acylated by diverse aldehydes with good yields. Bode et al. reported an enentioselective oxidative approach for the synthesis of dihydropyridinones via an NHC-catalyzed aza-Claisen rearrangement   Less popular than the two-electron oxidation of the Breslow intermediate is oxidation via the SET process, in which instead of an acylazolium ion, a very reactive radical cation species is generated. These intermediates can undergo reactions with other radicals present in the reaction mixture. Li, Webster and Chi reported the β,β-coupling of α,β-unsaturated nitroalkanes in the presence of aldehyde, methanol and an NHC catalyst in 2014 ( Figure 20) [69]. SET oxidation was guaranteed by pyruvate ferredoxin oxidoreductase (PFOR). Structurally complex products were obtained with high yields and moderate diastereomeric excesses. Sun and Ye developed the oxidative [3 + 2] annulation of dioxindoles and enals in 2017 [70]. The expected products were obtained in the efficient radical cross-coupling of homoenolate or enolate. Nitrobenzene was used as an oxidizing agent and triazolium salts as precatalysts ( Figure 21). The developed approach was distinguished as a highly diastereoselective and enantioselctive method. One year later, Ye et al. reported a similar synthesis using β,β-disubstituted enals [71].   Sun and Ye developed the oxidative [3 + 2] annulation of dioxindoles and enals in 2017 [70]. The expected products were obtained in the efficient radical cross-coupling of homoenolate or enolate. Nitrobenzene was used as an oxidizing agent and triazolium salts as precatalysts ( Figure 21). The developed approach was distinguished as a highly diastereoselective and enantioselctive method. One year later, Ye et al. reported a similar synthesis using β,β-disubstituted enals [71]. Sun and Ye developed the oxidative [3 + 2] annulation of dioxindoles and enals in 2017 [70]. The expected products were obtained in the efficient radical cross-coupling of homoenolate or enolate. Nitrobenzene was used as an oxidizing agent and triazolium salts as precatalysts ( Figure 21). The developed approach was distinguished as a highly diastereoselective and enantioselctive method. One year later, Ye et al. reported a similar synthesis using β,β-disubstituted enals [71].
Sun and Ye developed the oxidative [3 + 2] annulation of dioxindoles and enals in 2017 [70]. The expected products were obtained in the efficient radical cross-coupling of homoenolate or enolate. Nitrobenzene was used as an oxidizing agent and triazolium salts as precatalysts ( Figure 21). The developed approach was distinguished as a highly diastereoselective and enantioselctive method. One year later, Ye et al. reported a similar synthesis using β,β-disubstituted enals [71].   Recently Zeitler and Connon have reported oxidative esterification of aldehydes occurring via oxidation of benzoin, generated by the condensation of two molecules of benzaldehydes [77]. Furthermore, the obtained benzidin reacts with carbene to give the Breslow intermediate, which subsequently reacts with the corresponding alcohol. After elimination, esters of benzoic acids are obtained with good yields (Figure 23). In 2015 Sudalai et al. reported the synthesis of α,β-epoxyketones via the oxidative NHCcatalyzed coupling of alkenes with aldehydes [78]. Styrene derivative was firstly oxidized by NBS (N-bromosuccinimide) and DMSO to phenacyl bromide. The resulting acylazolium reacted then with a second molecule of aldehyde and, after elimination, α,β-epoxyketones were obtained with moderate to good yields ( Figure 24). Recently Zeitler and Connon have reported oxidative esterification of aldehydes occurring via oxidation of benzoin, generated by the condensation of two molecules of benzaldehydes [77]. Furthermore, the obtained benzidin reacts with carbene to give the Breslow intermediate, which subsequently reacts with the corresponding alcohol. After elimination, esters of benzoic acids are obtained with good yields (Figure 23).  Recently Zeitler and Connon have reported oxidative esterification of aldehydes occurring via oxidation of benzoin, generated by the condensation of two molecules of benzaldehydes [77]. Furthermore, the obtained benzidin reacts with carbene to give the Breslow intermediate, which subsequently reacts with the corresponding alcohol. After elimination, esters of benzoic acids are obtained with good yields (Figure 23). In 2015 Sudalai et al. reported the synthesis of α,β-epoxyketones via the oxidative NHCcatalyzed coupling of alkenes with aldehydes [78]. Styrene derivative was firstly oxidized by NBS (N-bromosuccinimide) and DMSO to phenacyl bromide. The resulting acylazolium reacted then with a second molecule of aldehyde and, after elimination, α,β-epoxyketones were obtained with moderate to good yields ( Figure 24). In 2015 Sudalai et al. reported the synthesis of α,β-epoxyketones via the oxidative NHC-catalyzed coupling of alkenes with aldehydes [78]. Styrene derivative was firstly oxidized by NBS (N-bromosuccinimide) and DMSO to phenacyl bromide. The resulting acylazolium reacted then with a second molecule of aldehyde and, after elimination, α,β-epoxyketones were obtained with moderate to good yields ( Figure 24).
In 2015 Sudalai et al. reported the synthesis of α,β-epoxyketones via the oxidative NHCcatalyzed coupling of alkenes with aldehydes [78]. Styrene derivative was firstly oxidized by NBS (N-bromosuccinimide) and DMSO to phenacyl bromide. The resulting acylazolium reacted then with a second molecule of aldehyde and, after elimination, α,β-epoxyketones were obtained with moderate to good yields ( Figure 24).

Oxidative NHC Catalysis via Electrolysis
The Breslow intermediate can also be oxidized to an acylazolium ion by anodic electrochemical oxidation. Cyclic voltammograms of Breslow intermediates lead to low oxidation potentialsapproximately 0.5 V for first and 0.9 V for second step of the oxidation [79]. In 2012, Boydstone and co-workers reported the synthesis of esters in an NHC-catalyzed reaction of aldehydes and alcohols in an undivided electrochemical cell ( Figure 25) [80]. Essentially, the reaction procedure with oxidation of the Breslow intermediate via electrolysis does not differ from an approach with an external oxidizer. The fundamental difference is the necessity of an electrolyte addition. In Boystone's work, tetrabutylammonium bromide (TBAB) was added as an electrolyte. The expected esters were obtained with excellent yields.

Oxidative NHC Catalysis via Electrolysis
The Breslow intermediate can also be oxidized to an acylazolium ion by anodic electrochemical oxidation. Cyclic voltammograms of Breslow intermediates lead to low oxidation potentials-approximately 0.5 V for first and 0.9 V for second step of the oxidation [79]. In 2012, Boydstone and co-workers reported the synthesis of esters in an NHC-catalyzed reaction of aldehydes and alcohols in an undivided electrochemical cell ( Figure 25) [80]. Essentially, the reaction procedure with oxidation of the Breslow intermediate via electrolysis does not differ from an approach with an external oxidizer. The fundamental difference is the necessity of an electrolyte addition. In Boystone's work, tetrabutylammonium bromide (TBAB) was added as an electrolyte. The expected esters were obtained with excellent yields.  [81] and amides [82] using a microflow electrochemical cell ( Figure 26). Although good product yields were achieved, Brown's procedure has an enormous disadvantage-NHC salt must be added as an equimolar reagent. Boydstone's group showed a similar procedure of thioesters synthesis in an undivided cell in 2014 [83]. The reported approach enables product synthesis with good-to-excellent yields, but disulfide byproducts were observed in some cases.

Conclusions
N-Heterocyclic carbene catalysis under oxidizing conditions enables several diverse synthetic approaches. Various oxidizing mechanisms, oxidizers, and exploitation of domino reactions or  [81] and amides [82] using a microflow electrochemical cell ( Figure 26). Although good product yields were achieved, Brown's procedure has an enormous disadvantage-NHC salt must be added as an equimolar reagent. Boydstone's group showed a similar procedure of thioesters synthesis in an undivided cell in 2014 [83]. The reported approach enables product synthesis with good-to-excellent yields, but disulfide byproducts were observed in some cases.  [81] and amides [82] using a microflow electrochemical cell ( Figure 26). Although good product yields were achieved, Brown's procedure has an enormous disadvantage-NHC salt must be added as an equimolar reagent. Boydstone's group showed a similar procedure of thioesters synthesis in an undivided cell in 2014 [83]. The reported approach enables product synthesis with good-to-excellent yields, but disulfide byproducts were observed in some cases.

Conclusions
N-Heterocyclic carbene catalysis under oxidizing conditions enables several diverse synthetic approaches. Various oxidizing mechanisms, oxidizers, and exploitation of domino reactions or

Conclusions
N-Heterocyclic carbene catalysis under oxidizing conditions enables several diverse synthetic approaches. Various oxidizing mechanisms, oxidizers, and exploitation of domino reactions or cooperative catalysis extends the capabilities and applications of NHC catalysis under oxidizing conditions in organic synthesis. This branch of organocatalysis has been extensively developed in recent years, giving hope for the future discovery of novel elegant synthetic procedures. Significantly large amounts of complex organic molecules and important substrates in the total synthesis of natural products and pharmaceuticals can be obtained via procedures implementing oxidative and oxygenative NHC catalysis. Many esters, amides, thioesters, lactones, and lactames-frequently enantioenriched-synthesized by organocatalytic approaches can be very appropriable reactants in sophisticated syntheses. The future development of NHC catalysis under oxidizing conditions probably will be premised on electroorganic chemistry and photochemistry. Increasingly ideal equipment for electrosynthesis and common applications of photoinduced reactions in organocatalysis are leading to progress in this branch of organic chemistry.